产品名：重组人白介素17 (IL-17A)

产品信息：LT0125

IL-17A 是通过胱氨酸连接的同型二聚体，通过独特的CD4+ T细胞系产生的促炎症细胞因子。IL-17A 刺激促炎症因子IL-1β, TNF-α,和IL-6的产生。IL-17A 也能够诱导产生噬中性粒细胞趋化剂如IL-8, CXCL1和 CXCL6，这样就将天然免疫和获得性免疫连接起来。IL-17A跟粘膜抵抗细菌侵染有密切的联系，同时也在自身免疫混乱过程中有潜在的功能。IL-17A 通过结合到 IL-17RA发挥作用。IL-17A与IL-17RA的结合通过激活Erk1/2 MAP激酶, PI3K/Akt, p38, 和 NF-κB 信号通路诱导产生细胞因子，趋化因子和一些相关的蛋白。它也能够磷酸化一些 Jaks 和 Stats 家族的蛋白。

别名:

IL-17, CTLA-8

英文描述:

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant Human IL-17A is a 31.3 kDa, disulfide-linked homodimer of two 137 amino acid, polypeptide chains.

表达宿主来源:

E.coli

氨基酸序列:

MIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

保存条件：4℃保存6个月，-20℃保存一年或-80℃长期保存。

纯度&内毒素

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level<0.5EU//μg

The purity of rhIL-17 was determined by SDS-PAGE of  rhIL-17 and staining overnight with Coomassie Blue.