产品名：重组小鼠TNFβ

产品号：LT-0236

产品信息：

TNF-β是炎症和免疫反应强有力的调节子。它属于TNF家族的配体，并通过TNFR1和TNFR2传递信号。TNF-β由激活的T和B淋巴细胞产生，和TNF-α具有类似的活动。跟TNF-α一样，TNF-β参与各种生理过程的调解,包括细胞增殖、分化、凋亡,脂类代谢,凝固和神经传递。TNF-β分泌为可溶性多肽,但可以与有效固定TNF-β到细胞表面的lymphotoxin-β形成异三聚体。TNF-β对很多肿瘤细胞具有细胞毒性。重组体人TNF-β是172个氨基酸组成的分泌型蛋白(18.6 kDa)，在溶液中可形成具有活性的非二硫键链接的三聚体。

别名：Tumor Necrosis Factor-β, TNFSF1B, Lymphotoxin-alpha (LT-α)

英文描述：

TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands, and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-伪. Like TNF-α. TNF-β is involved in the regulation of various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant Human TNF-β is a secreted 172 amino acid protein (18.6 kDa) which forms an active non-disulfide-linked homotrimer structure in solution.

氨基酸序列:

MMSGVRFSAA RTAHPLPQKH LTHGILKPAA HLVGYPSKQN SLLWRASTDR AFLRHGFSLS NNSLLIPTSG LYFVYSQVVF SGESCSPRAI PTPIYLAHEV QLFSSQYPFH VPLLSAQKSV YPGLQGPWVR SMYQGAVFLL SKGDQLSTHT DGISHLHFSP SSVFFGAFAL

来源:

E.coli

保存条件：

4℃保存6个月，-20℃保存一年或者-80℃长期保存。

纯度&内毒素:

Greater than 90% by SDS-PAGE gel and HPLC analyses.

Endotoxin level <0.5EU/ug

The purity of rm TNFβwas determined by SDS-PAGE of non-reduced and reduced rm TNFβand staining overnight with Coomassie Blue.