产品名：重组人 4-1BB Ligand（4-1BB L）

产品号：LT0001

产品信息：

4-1BBL是TNF超家族的一员，在B细胞、树突状细胞、活化T细胞和巨噬细胞中表达。4-1BBL与受体4-1BB结合，为T细胞的活化和扩增提供协同刺激信号。人4-1BBL基因编码跨膜的254个氨基酸，包含28个氨基酸细胞质域，21个氨基酸跨膜域，和205个氨基酸胞外域。4-1BBL的可溶性形式包含4-1BBL细胞外域的TNF样部分。重组人4-1BBL是一种可溶解的19.5 kDa蛋白质，由185个氨基酸残基组成。

别名：

TNFSF9, CD137L

描述

4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

表达宿主来源:

E.coli

氨基酸序列

MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE

保存条件：

4℃保存6个月，-20℃保存一年或者-80℃长期保存

纯度&内毒素:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level <0.5EU/ug