tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcolasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store operated Ca2+ depletion. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion.
郑重提醒：艾美捷科技最专业的离子通道研究工具供应商Alomone的中国区代理，我们为您提供的如下生命科学领域研究方案享誉海内外：离子通道研究领域、G蛋白耦联受体研究领域、 神经信号通路研究。我们也将一如既往更加努力为国内用户提供快捷、方便的高质量产品，同时更为您售前售后全面技术支持。欢迎垂询：400-6800-868，www.amyjet.com