Trimethylapigenin is a natural flavone and a fully methylated derivate of apigenin, present in citrus, kaempferia parviflora, etc. Trimethylapigenin inhibits cardiac potassium currents. This compound blocks hKV1.5 current in HEK 293 cell line (IC50 = 6.4 μM), and the ultra-rapid delayed rectify K+ current (IKur) in human atrial myocytes (IC50 = 8.0 μM) by binding to the open channels. In addition, trimethylapigenin decreased transient outward K+ current (Ito) in human atrial myocytes, inhibited acetylcholine-activated K+ current (IC50 = 6.8 μM) in rat atrial myocytes.
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