Citalopram is an extremely potent inhibitor and highly selective bicyclic serotonin-reuptake inhibitor (SSRIs) with IC50 value of 275 nM1. The SSRIs selectively potentiate 5-HT neurotransmission by inhibiting serotonin reuptake. Citalopram competes with serotonin and imipramine for a common binding site. The high specificity results in minimal effects on other neurotransmitter receptors and uptake. Thus citalopram shows fewer of the anticholinergic or adrenolytic side effects associated with other psychotropic agents and it has minimal cardiotoxic side effects. Citalopram is structurally unrelated to other antidepressants, but it contains the chemical features associated with reversal of drug resistance2. Citalopram is used for the management of depression. Citalopram is also used for treating obsessive compulsive disorder (OCD), panic disorder, premenstrual dysphoric syndrome (PMDD), anxiety disorder, and posttraumatic stress disorder.
郑重提醒：艾美捷科技最专业的离子通道研究工具供应商Alomone的中国区代理，我们为您提供的如下生命科学领域研究方案享誉海内外：离子通道研究领域、G蛋白耦联受体研究领域、 神经信号通路研究。我们也将一如既往更加努力为国内用户提供快捷、方便的高质量产品，同时更为您售前售后全面技术支持。欢迎垂询：400-6800-868，www.amyjet.com