Chlorpromazine (CPZ) is a widely used PTZ. It has been reported that CPZ strongly affects the GABA-mediated inhibitory synaptic transmission by decreasing the amplitude and by accelerating the decay of miniature IPSCs (mIPSCs). A recent study showed that CPZ decreased the channel-opening frequency of nicotinic acetylcholine receptor (nAChR) and, thus, acted as a closed-channel blocker (IC50s values are ~10 µM).
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