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Omega-Conotoxin MVIIC【Omega-Conotoxin MVIIC (1 mg)】
  • 商城价格 登录后可查看价格
  • 货号 C-150-1
  • 品牌 alomone labs ( 经销商 )
  • CAS号 见包装
  • 规格/包装 1 mg
  • 单位
  • 储存条件 见包装
  • 现货状态 一个月

  • 数量

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ω-Conotoxin MVIIC, blocks CaV2.1 (α1A, P/Q-type) and Cav2.2 (α1B, N-type) channels. The toxin binds with high affinity to Cav2.1 and with lower affinity to Cav2.2 in rabbit brain. However, the block by ω-Conotoxin-MVIIC, of N-type channels in DRG neurons developed much faster than the block of P-type currents in Purkinje cells. The effect of the toxin is modulated by voltage (i.e. it is more potent for inactivated channels). In addition this toxin was reported to block nicotinic receptors (transiently expressed in Xenopus oocytes) with IC50 of 1.3 µM. It was also shown to inhibit K+-induced 3H-GABA release in hippocampus in vivo. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations.
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