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ω-Conotoxin MVIIC, blocks CaV2.1 (α1A, P/Q-type) and Cav2.2 (α1B, N-type) channels. The toxin binds with high affinity to Cav2.1 and with lower affinity to Cav2.2 in rabbit brain. However, the block by ω-Conotoxin-MVIIC, of N-type channels in DRG neurons developed much faster than the block of P-type currents in Purkinje cells. The effect of the toxin is modulated by voltage (i.e. it is more potent for inactivated channels). In addition this toxin was reported to block nicotinic receptors (transiently expressed in Xenopus oocytes) with IC50 of 1.3 µM. It was also shown to inhibit K+-induced 3H-GABA release in hippocampus in vivo. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations.郑重提醒:艾美捷科技最专业的离子通道研究工具供应商Alomone的中国区代理,我们为您提供的如下生命科学领域研究方案享誉海内外:离子通道研究领域、G蛋白耦联受体研究领域、 神经信号通路研究。我们也将一如既往更加努力为国内用户提供快捷、方便的高质量产品,同时更为您售前售后全面技术支持。欢迎垂询:400-6800-868,www.amyjet.com