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CD137, also known as 4-1BB, is a TNFR family member expressed on activated T cells, NK cells, and a number of other activated cells of hematopoietic and non-hematopoietic origin. Its ligand, 4-1BBL, is expressed by activated DCs, B cells, and macrophages. This interaction leads to a co-stimulatory signal that promotes the up-regulation of anti-apoptotic molecules such as Bcl2 and Bcl-xL. 4-1BB plays roles in promoting cell proliferation and survival of antigen-specific T cells.