G7959Print Name TO3-3PEG-Biotin Fluorophore Unit 250 µM (100 µl) Category RNA Tracking (RNA Mango) Description RNA Mango technology is based on the specific binding of the RNA Mango Aptamer and a Thizole Orange (TO) bi-functional fluorophore dye. The main features of this technology is the tight binding between the dye and aptamer (KD ≈ 3nM) , and the strong ~1000X enhancement of the dye’s fluorescence when bound to the Mango apatmer (Fluorescent enhancement FE=1,100). The TO fluorophore dye has a number of other desirable properties including: small size lack of toxicity plasma and nuclear membrane permeability short intracellular half-life the accessibility of a broad wavelength range simply via substitutions and alterations to the TO structure TO1 and TO3 dyes can be used in a 2-color reporter assay system using both the RNA Mango and RNA Peach Aptamer systems (Kong et. al. 2021) Learn more about the RNA Mango technology here.