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TRIM25 Rabbit mAb

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产品详情

Product Name

TRIM25 Rabbit mAb
Gene ID

7706
SwissProt ID

Q14258
Gene Name

TRIM25
Alternative Names

TRIM25; EFP; RNF147; ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147
Background

Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection.
Research Field

Cell Biology
Product Categories

Recombinant Rabbit Monoclonal antibody
Host

Rabbit
Reactivity

Human,Rat
Application

WB,ICC/IF,IP
Dilution Ratio

WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Molecular Weight

Calculated MW: 71 kDa; Observed MW: 71 kDa
Clonality

Monoclonal Antibody
Clonality No.

R06-1H2
Isotype

IgG
Immunogen

A synthetic peptide of human TRIM25
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.