Plasmid pcDNA/FL-RAGE contains the cDNA that corresponds to full-length, membrane bound human RAGE (FL-RAGE). It expresses FL-RAGE when transiently transfected in mammalian cells. The full-length protein is cleaved by membrane proteases; the soluble cleaved protein (cRAGE) can be recovered from the culture supernatant. The expressed proteins (FL-RAGE and cRAGE) contain no tags. Pubblications where this product was used: See Raucci et al. A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). FASEB J 2008 Jul 4. [Epub ahead of print]